Comroe left Pennsylvania in 1958 to become the Director of the newly formed Cardiovascular Research Institute (CVRI) at the University of California School of Medicine in San Francisco. Under his direction the CVRI added courses in mathematics, statistics, physics, and biophysics to the regular school of medicine curriculum and sponsored special workshops, weekly research seminars, and weekly cardiopulmonary physiology conferences. During his many years as chief of the CVRI, he became one of the most respected and admired UCSF faculty members. He received an honorary Doctor of Medicine degree from the Karolinska Institute, Stockholm in 1968, and an honorary Doctor of Science degree from the University of Chicago in 1968. He was elected to the National Academy of Sciences and the American Academy of Arts and Sciences. He was a founding member of the Institute of Medicine. He was made a Fellow of the Royal College of Physicians, London, in 1971. Comroe wrote two widely used books, The Lung: Clinical Physiology and Pulmonary Function Tests, and Physiology of Respiration. Both were translated into many languages and used around the world. He was on numerous Editorial Boards, and was editor of Circulation Research, and Annual Review of Physiology.
He resigned as Director of the CVRI in 1973 to devote full time to research, teaching and writing. His leadership at CVRI created an organization with a renowned staff, successful multidisciplinary research, and a fellowship program that trained hundreds of young research scientists from many countries.References: